Hexahydronaphthalene ester derivatives their preparation and their therapeutic uses

摘要

Compounds of formula (I): [wherein R<1> represents a group of formula (II) or (III): R<2> is hydrogen or a group of formula -OR<3>; R<3>, R<3a> and R<3b> are each hydrogen, a hydroxy-protecting group, alkyl, alkanesulphonyl, halogenated alkanesulphonyl or arylsulphonyl; R<4> is hydrogen or a carboxy-protecting group; R<5> is alkyl, alkenyl, alkynyl, aryl, aralkyl or a fused polycycle; and W is alkylene] and their salts and esters have the ability to inhibit the synthesis of cholesterol, and can thus be used for the treatment and prophylaxis of hypercholesterolemia and of various cardiac disorders.