Amide derivatives and 5-lipoxygenase inhibitors containing the same as an active ingredient.

摘要

Provided are amide derivatives having the general formula (I): wherein R<1> represents hydrogen atom or an alkyl group, R<2> represents hydrogen atom, an alkyl group or toluoyloxy group, or R<1> and R<2> when taken together represent an alkylene group, R<3> represents hydrogen atom or an alkoxy group, R<2> and R<3> both being hydrogen atom when R<1> represents hydrogen atom, and n is an integer of 1 or 2; Y represents an amino group having the formula wherein X<6> represents hydrogen atom, a halogen atom or an alkoxy group. The above-mentioned compounds have been demonstrated to possess 5-lipoxygenase-inhibiting activities. These compounds can inhibit the production of leucotrienes such as LTC4 and LTD4 which are allergy-inducing factors by inhibiting the activity of 5-lipoxygenase. Accordingly, the amide derivatives can be used as 5-lipoxygenase inhibitors effective for allergic asthma, allergic rhinitis and the like.