发明名称 |
Alcohol or aldehyde derivatives as cathepsin L inhibitor and bone resorption inhibitor. |
摘要 |
<p>The present invention provides a cathepsin L inhibitor containing a compound of the formula: <CHEM> wherein R<1> is a hydrogen atom or an arylalkyl, heterocyclic-alkyl or lower alkyl group which may be substituted; R<2> and R<3> independently are a hydrogen atom or a hydrocarbon residue which may be substituted; R<4> is an alkanoyl, sulfonyl, carbonyloxy, carbamoyl or thiocarbamoyl group which may be substituted; X is formula: -CHO or -CH2OB (wherein B is a hydrogen atom or a protecting group of hydroxyl group); m and n independently are an integer of 0 or 1; provided that R<4> is an alkanoyl group substituted by aryl, a sulfonyl group substituted by aryl having more than 9 carbon atoms or by lower alkyl, or a carbamoyl or thiocarbamoyl group which may be substituted when R<1> is an unsubstituted lower alkyl, arylalkyl on methylthioethyl group, R<2> and R<3> independently are a lower alkyl or arylalkyl, X is -CHO, m is 1 and n is 0 or 1, or a salt thereof. Compound (I) is useful as a prophylactic/therapeutic agent for osteoporosis.</p> |
申请公布号 |
EP0611756(A2) |
申请公布日期 |
1994.08.24 |
申请号 |
EP19940102404 |
申请日期 |
1994.02.17 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
SOHDA, TAKASHI;FUJISAWA, YUKIO;YASUMA, TSUNEO;MIZOGUCHI, JUNJI;KORI, MASAKUNI;TAKIZAWA, MASAYUKI |
分类号 |
A61K38/55;A61K31/16;A61K31/165;A61K31/18;A61K31/27;A61K38/00;A61P3/00;A61P3/02;A61P43/00;C07C231/12;C07C233/18;C07C233/22;C07C233/31;C07C237/10;C07C237/22;C07C271/16;C07C271/18;C07C271/22;C07C303/40;C07C311/19;C07C337/02;C07D209/14;C07D209/16;C07K1/113;C07K5/06;C07K5/062;C07K14/81;(IPC1-7):C07D209/16;C07D405/12;C07D403/12;A61K31/40 |
主分类号 |
A61K38/55 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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