| 摘要 |
Solid, water-insoluble lipospheres including a solid hydrophobic core, having a layer of a phospholipid embedded on the surface of the core, that contain an antigen are disclosed for use in immunizing an animal. The antigen (or "immunogen"), alone or in combination with a carrier, can form the core, be attached to or within the phospholipid, or both. Lipospheres containing antigens are prepared by two general procedures, either melt preparation or solvent preparation. The resulting lipospheres have several advantages over other delivery systems, including emulsions, vesicles and liposomes, including stability, low cost of reagents, ease of manufacture, high dispersibility in an aqueous medium, a release rate for the entrapped substance that is controlled by the phospholipid coating and the carrier.
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