发明名称 |
Alkaline ophthalmic suspensions |
摘要 |
Topical ophthalmic medicament delivery system combining an aqueous ophthalmic gel suspension at a pH equal to or greater than 7.5 and an osmotic pressure of from 10 to about 400 mOsM containing a pharmaceutically effective amount of one or more ophthalmic medicaments of from about 0.05% to about 10% by weight, based on the total weight of the suspension, of a carboxyl-containing polymer prepared by polymerizing one or more carboxyl-containing monoethylenically unsaturated monomers and less then about 5% by weight of a cross-linking agent. The systems have a viscosity of from about 1,000 to about 30,000 centiposes prior to administration to the eye and remain a gel in the eye for a prolonged period of time allowing for the sustained release of one or medicaments such as amine containing antibiotics alone or in combination with cortiscosteroids.
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申请公布号 |
US5340572(A) |
申请公布日期 |
1994.08.23 |
申请号 |
US19930014512 |
申请日期 |
1993.02.08 |
申请人 |
INSITE VISION INCORPORATED |
发明人 |
PATEL, RAJESH;BOWMAN, LYLE;VILDAVER, MARGARITA;CHEN, RAYMOND |
分类号 |
A61K9/107;A61K9/00;A61K47/32;(IPC1-7):A61K31/74;A61K9/14;A61F2/14 |
主分类号 |
A61K9/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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