CONTROL OF CELL PROLIFERATION

摘要

Methods are provided for identifying agents useful for decreasing undesired cell proliferation, e.g., to treat a neoplasm. Methods are also provided for identifying agents useful for inducing the replication of cells in a terminally differentiated state in order to, e.g., regenerate a damaged tissue, e.g., muscle, neural, or epithelial, or hematopoietic tissue. The agents useful in the invention either enhance or decrease the interaction between a pocket protein, e.g., retinoblastoma protein, and a tissue-specific transcription factor, e.g., members of the MyoD, MEF2, or MASH families of transcription factors.