| 发明名称 |
Diarylalkyl piperidines useful as multi-drug resistant tumor agents |
| 摘要 |
PCT No. PCT/US93/12300 Sec. 371 Date Mar. 11, 1996 Sec. 102(e) Date Mar. 11, 1996 PCT Filed Dec. 17, 1993 PCT Pub. No. WO94/17040 PCT Pub. Date Aug. 4, 1994Diarylalkyl piperidines of formula (1) <IMAGE> (1) reverse drug resistance in multi-drug resistant tumors. These compounds apparently function by inhibiting a p-glycoprotein pump which becomes activated in late stage tumor development and which is inherently present in tumors from certain origins. |
| 申请公布号 |
ZA9400317(B) |
申请公布日期 |
1994.08.18 |
| 申请号 |
ZA19940000317 |
申请日期 |
1994.01.17 |
| 申请人 |
MERRELL DOW PHARMACEUTICALS INC. |
发明人 |
SAI P SUNKARA;JULES FREEDMAN |
| 分类号 |
A61K31/4427;A61K31/443;A61K31/445;A61K31/451;A61K31/4525;A61K31/454;A61P35/00;A61P43/00;C07D211/16;C07D211/18;C07D211/22;C07D401/06;C07D405/06 |
主分类号 |
A61K31/4427 |
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