| 摘要 |
<p>The invention relates to a tumor necrosis factor mutein characterized in that the TNF-α amino acid sequence is mutated, or deleted totally or partially, in the region extending from amino acid position at 101 to 116 in such a way that: either the lectin-like activities are modulated with respect to TNF-α, and/or the toxic activity is reduced with respect to TNF-α, and/or the inflammatory cytokines inducing capacities are modulated with respect to TNF-α, and/or the adhesion molecules inducing capacities are modulated with respect to TNF-α, and/or the metastasis promoting activity is reduced with respect to TNF-α, and/or the half life time is increased with respect to TNF-α and with said muteins being characterized in that they have retained the aforementioned activities; or a pharmaceutically acceptable salt thereof.</p> |
