| 摘要 |
Compounds having chemical formula (I): wherein R<1> is hydrogen, hydroxy, C1-C6alkoxy, tri(C1-C6alkyl)silyloxy or acyloxy; R<2> is C1-C6alkyl; and Ar is optionally substituted aryl. The compounds and their pharmaceutcally acceptable salts have excellent activity as opioid kappa -receptor agonists. They are useful for the treatment and prevention of pain, asthma, scabis, psoriasis vulgaris or inflammation, especially pain, in mammalian subjects, e.g., human subjects. |
