DEVICE FOR ADMINISTERING DRUG TRANSDERMALLY WITH A CONTROLLED TEMPORAL CHANGE IN SKIN FLUX.

摘要

PCT No. PCT/US92/08631 Sec. 371 Date Mar. 16, 1994 Sec. 102(e) Date Mar. 16, 1994 PCT Filed Oct. 9, 1992 PCT Pub. No. WO93/06803 PCT Pub. Date Apr. 15, 1993A transdermal drug delivery device that administers drug in an initial pulse followed by a substantially lower continuous rate comprising a drug reservoir of the drug dissolved in a nonvolatile skin permeation enhancer and a volatile permeation enhancer confined between a backing that is permeable to the volatile permeation enhancer and an underlying substrate layer that is permeable to the drug and both enhancers. When the device is placed on the skin the volatile permeation enhancer is depleted from the reservoir by evaporation through the backing such that the magnitude and duration of the pulse is dependent upon the permeability of the backing layer to the volatile enhancer.