PROCESS FOR PRODUCING 4-HYDROXY-L-PROLINE

摘要

A process for producing 4-hydroxy-L-proline by the conversion of 4-hydroxy-2-oxoglutaric acid in an aqueous medium in the presence of an amino group donor and an enzyme source belonging to the genus Escherichia and capable of converting 4-hydroxy-2-oxoglutaric acid into 4-hydroxy-L-proline; and a microorganism which belongs to the genus Escherichia, holds a recombinant DNA incorporating a gene coding for gamma -glutamylkinase released from the feedback inhibition caused by L-proline, and contains the above enzyme source.