Detection of biological macromolecules by NMR-sensitive labels

摘要

An apparatus and method for identifying the presence of biological molecules labeled with isotopes that are identifiable and distinguishable by their responses to nuclear magnetic resonance. The method features the use of labels that are: 1) not radioactive or only weakly radioactive, therefore not hazardous to handle, and have a long storage life. 2) small in molecular weight, thus not significantly changing the electrophoresis migration rate of the labeled material. 3) available as several distinguishable labels, thereby enabling simultaneous detection of several classes of molecules.