OLIGOPEPTIDES WITH CYCLIC PROLINE-ANALOGOUS AMINO ACIDS

摘要

of the disclosure Oligopeptides with cyclic proline-analogous amino acids The invention relates to compounds of the formula I (I) <IMG> in which A denotes an optionally substituted radical from the series comprising alkyl, acyl, cycloalkyl, aryl and heteroaryl; Cyc represents an optionally substituted heterocyclic carbonyl compound; D represents NH, NCH3, O or CH2; E represents CHOH, CO, SO or optionally Nsubstituted C=NH; F represents O, NH, NCH3 or a bond; R4 denotes an optionally substituted radical from the series comprising alkyl, cycloalkyl, aryl and heteroaryl; and R8 denotes hydrogen or optionally substituted alkyl, to a process for the preparation thereof, and to the use thereof as inhibitors of prolyl hydroxylase.