摘要 |
A process for producing live, non-pathogenic, vaccines for the pathogens RNA turmor virus utilizes gene-altering technology to produce an altered genome which codes for the antigenic determinants of a pathogen, but has no genes coding for pathogenicity. The vaccine is the phenotypic expression of the altered genome. Specifically, an avian RNA tumor virus env gene is cloned into the non-pathogenic RNA virus RAV-O and the resulting recombinant product is replicated in host cells to provide a recombinant vaccine for the pathogen avian RNA tumor virus.
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