Method of identifying inhibitors of beta -protein esterase activity

摘要

Disclosed is a method for identifying a compound which inhibits the esterase activity of beta -protein. More specifically, in the method disclosed, beta -protein is combined with an appropriate substrate and a compound to be tested for its ability to inhibit the enzymatic activity of beta -protein (candidate inhibitor). Failure of beta -protein to act upon the substrate is an indication that the candidate inhibitor is, in fact, effective as an inhibitor of the beta -protein activity. Specifically, the extent to which beta -protein acts upon the substrate is determined and compared with the extent to which beta -protein acts upon the substrate in the absence of the candidate inhibitor.