| 摘要 |
The present invention is directed to a polynucleotide, of about 10 to about 50 nucleic acid bases in length, which hybridizes to the gene encoding raf. The present invention is also directed to a pharmaceutical composition comprising the above polynucleotide dissolved or dispersed in a physiologically tolerable diluent. The present invention is further directed to a process for inhibiting vascular smooth muscle cell proliferation, a process for treating vascular smooth muscle cell proliferation, and process for treating a disease state involving smooth muscle cell proliferation. These processes comprise contacting the vascular smooth muscle cells or administering to a host mammal in need of such treatment, an effective amount of a polynucleotide of about 10 to about 50 nucleic acid bases in length, said polynucleotide hybridizing to the gene for raf. |
