Spiro-substituted azacycles as tachykinin receptor antagonists

摘要

PCT No. PCT/US94/00819 Sec. 371 Date Jul. 11, 1995 Sec. 102(e) Date Jul. 11, 1995 PCT Filed Jan. 25, 1994 PCT Pub. No. WO94/17045 PCT Pub. Date Aug. 4, 1994Disclosed are spiro-substituted azacycles of formula (I), are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, emesis and asthma. In particular compounds of formula (I) are shown to be neurokinin antagonists. (I)