| 摘要 |
A method for testing the ability of a drug to interfere with development of neoplasia is described. A tumor cell having a transformation sensitive reporter unit is introduced into a recipient organism under a condition which reduces the recipient organism's rejection of the tumor cell, a drug is administered to this organism, and a determination is made as to whether the drug has affected the expression of a structural gene that is part of the transformation sensitive reporter unit by assaying for the expressed product of the structural gene. Preferably, the method also includes prescreening the drug by administering the drug to a culture of the tumor cells that have the transformation sensitive reporter unit. Tumor cells and organisms having a transplanted tumor cell are also provided. |
