Vaccines and methods for preventing and treating fescue toxicosis in herbivores

摘要

An immunogenic compound comprising the formula: wherein X is selected from the group consisting of methyl and hydrogen; wherein R1 is a suitable functional group of the lysergic ring; wherein R2 is an immunogenic protein; and wherein Y is a bridge to link R1 to R2. Purified polyclonal and monoclonal antibodies specifically reactive with the immunogenic compound and reactive with the lysergic ring of ergopeptine and clavine alkaloids are described. An antibody which is an anti-idiotype of the monoclonal antibody is provided. Methods of prevention and treatment of fescue toxicosis utilizing the immunogenic compounds and antibodies of the present invention are provided.