| 摘要 |
The invention relates to cephalosporin salts of the general formula (I), [cephalosporin]<m(-)>x[BxH<+>]<(+)>n (I> in which the salt-forming anion contains an antibiotically active cephalosporin having a group (m = 1) which is capable of anion formation, or having several groups of this nature (m = 2 or 3), and the base, which can be present as a pure (+) or (-) enantiomer or in racemic form, possesses the general formula (B), <IMAGE> R<1> is straight-chain or branched alkyl having 1-8 C atoms which is optionally substituted by hydroxyl or phenyl or by phenyl which is substituted by alkoxy or halogen; preferably is a methyl, ethyl, propyl, butyl or benzyl group, R<2>, R<3>, R<4> and R<5> can be identical or different and be hydrogen or straight-chain or branched alkyl having 1-4 C atoms, R<2> preferably being propyl, R<3> and R<4> preferably being methyl, and R<5> preferably being hydrogen, and m and n depending on the number of salt-forming groups in the cephalosporin moiety, have a number of from 1 to 3 for m, preferably 1 and 2, and for n 0.1 to 3, preferably 0.1 to 2. The cephalosporin salts according to the invention possess very good antibacterial activity and can therefore be used as drugs (medicaments, pharmaceuticals, medicines). |
