| 摘要 |
<p>PURPOSE:To obtain a new compound, having pharmacological activities such as inhibiting activities against collagenases and useful for treating and/or preventing diseases mediated by the collagenases. CONSTITUTION:This compound is expressed by formula I (R<1> is H or a hydroxy- protecting group; R<2> is H, a lower alkyl or an amino-protecting group; R<3> is H or 2-thuenylthuo; R<4> is 2-pyridyl or its N-oxide, 4-pyridyl, phenyl or 4- methoxyphenyl; R<5> is hydroxy, a lower alkoxy or amino having a substituent group, with the proviso that R<4> is 2-pyridyl or its N-oxide or 4-pyridyl when R<1> and R<2> are each H) or its pharmaceutically permissible salt, e.g. [(2R,3 S)-4-(hydroxylamino)-2-isobutyl-3-(2-thienylthiomethyl)succinyl]-L-2-p yridylalanine- N-methylamide. The compound is obtained by reacting a compound of formula II or its reactive derivative or salt with a compound of formula III or lts reactive derivative or salt.</p> |
