发明名称 |
Use of charged phospholipids to reduce nanoparticle aggregation |
摘要 |
This invention discloses a composition comprised of nanoparticles having a non-ionic surfactant as a surface modifier adsorbed on the surface thereof and a charged phospholipid as a cloud point modifier associated therewith, which cloud point modifier is present in an amount sufficient to increase the cloud point of the surface modifier. A preferred non-ionic surfactant surface modifier is a poloxamine or tyloxapol, and preferred charged phospholipid cloud point modifiers include dimyristoyl phosphatidyl glycerol. This invention further discloses a method of making nanoparticles having a non-ionic surfactant as a surface modifier adsorbed on the surface and a charged phospholipid as a cloud point modifier associated therewith, comprised of contacting said nanoparticles with the cloud point modifier for a time and under conditions sufficient to increase the cloud point of the surface modifier.
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申请公布号 |
US5336507(A) |
申请公布日期 |
1994.08.09 |
申请号 |
US19920989281 |
申请日期 |
1992.12.11 |
申请人 |
STERLING WINTHROP INC. |
发明人 |
NA, GEORGE C.;RAJAGOPALAN, NATARAJAN |
分类号 |
A61J3/02;A61K9/14;A61K9/51;A61K47/00;A61K47/30;A61K47/34;A61K47/48;A61K49/04;A61L2/00;(IPC1-7):A61K9/14 |
主分类号 |
A61J3/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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