Inhibition of bone loss by 4-aryloxy-5-hydroxy-2(5H)-furanones

摘要

This invention relates to 4-phenoxy (and 4-substituted phenoxy)5-hydroxy-2(5H)-furanones of the formula: <IMAGE> where Z is <IMAGE> <IMAGE> 8 alkyl, C3-C8 cycloalkyl, trifluoromethyl, or <IMAGE> and X is H, C1-C8 alkyl, -O-C1-C8 alkyl, or halogen; a process for their preparation, their use in the treatment of osteoporosis, and pharmaceutical compositions thereof.