发明名称 |
OLIGONUCLEOTIDE ALKYLPHOSPHONATES AND ALKYLPHOSPHONOTHIOATES |
摘要 |
Disclosed is an oligonucleotide analog comprising at least one ribonucleotide alkylphosphonate or alkylphosphonothioate. This analog is preferably from 2 to 60 nucleotides in length and has at least one ribonucleotide substituted at the 2' position of its ribose group. Also disclosed are therapeutic formulations comprising this oligonucleotide analog, methods of inhibiting the expression of a gene from a virus, pathogenic organism, or cell, the expression of which is associated with a disease state, and methods of treating a mammal infected with a virus or pathogenic organism or afflicted with a disorder resulting from the expression of a cellular gene. |
申请公布号 |
WO9417093(A1) |
申请公布日期 |
1994.08.04 |
申请号 |
WO1994US00902 |
申请日期 |
1994.01.25 |
申请人 |
HYBRIDON, INC.;KANDIMALLA, EKAMBAR, R.;TEMSAMANI, JAMAL;AGRAWAL, SUDHIR |
发明人 |
KANDIMALLA, EKAMBAR, R.;TEMSAMANI, JAMAL;AGRAWAL, SUDHIR |
分类号 |
C07H21/04;A61K31/70;A61P31/04;A61P31/12;C07H21/00;C12N15/113;(IPC1-7):C07H21/00;C12N15/11 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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