| 摘要 |
<p>A process for preparing C-substituted diethylene triamines having general formula (I) is characterized in that a nitrogen-protected aminoethyl alcohol having general formula (II) is reacted with methane sulphonic acid chloride, tosyl chloride or trifluoroacetic acid anhydride in an organic solvent, with addition of a base, to give the corresponding mesylate, tosylate or triflate, is then filtered and the filtrate is reacted with an ethylene diamine having general formula (III) to give the desired nitrogen-protected, carbon-substituted triamine having general formula (I), in which R1 stands for a -(CH¿2?)m-(C6H4)q-(O)k-(CH2)n-(C6H4)l-(O)r-R group or for a -(CH2)m-(C6H10)q-(O)k-(CH2)n-(C6H10)l-(O)r-R group; R?2 and R3¿ each stand for a hydrogen atom or form together a -(CH¿2?)p-alkylene bridge; and R?4¿ stands for an amino protecting group, preferably for a benzyloxycarbonyl group.</p> |
