SLIDE IMMUNOASSAY DETECTION SYSTEM

摘要

A system and method for detecting and measuring an agglutination reaction as the agglutination reaction occurs at multiple sites distributed over a test slide's reaction chamber (typically a capillary channel). The detection system employs light stimulus sources having light emitting diodes, optical detection receivers having photodiodes, analog-to-digital converters, a microprocessor, and a liquid crystal display. Diffracted light is transmitted through a capillary action test slide's capillary channels at various strategical points and received by optical detectors, to monitor agglutination reaction dynamically. As the liquid assay flows through the channel(s), each photodiode synergistically with microprocessor control and measurement software, monitors the dynamic changes in optical density of the assay liquid. Each measurement is quantitized to result in a statistical calculation which can be compared to a set of thresholds (generated empirically) stored in the memory of the device. The agglutination reaction can then be characterized and displayed.