发明名称 |
N-(5,6,7,8-tetrahydropyrido(2,3-D)pyrimidin-6-yl-alkanoyl)-glutamic acid derivatives. |
摘要 |
<p>A compound selected from the group consisting of a glutamic acid derivative of the formula: <CHEM> in which: R<1> is -OH or -NH2; R<2> is hydrogen or a carboxy protecting group; R<3> is a carbon-carbon bond, alkylene of 1 to 4 carbon atoms, cyclohexylene, or <CHEM> R<4> is hydrogen or an amino protecting group; Q is -S- or -O-; R<5> is hydrogen, chloro or fluoro; and the configuration about the carbon atom designated * is S; and the pharmaceutically acceptable salts thereof. Also disclosed is a method of combatting neoplastic growth in a mammal and a pharmaceutical composition for combatting neoplastic growth in a mammal making use of the above compound.</p> |
申请公布号 |
EP0343801(B1) |
申请公布日期 |
1994.08.03 |
申请号 |
EP19890304499 |
申请日期 |
1989.05.04 |
申请人 |
THE TRUSTEES OF PRINCETON UNIVERSITY;ELI LILLY AND COMPANY |
发明人 |
TAYLOR, EDWARD C.;SHIH, CHUAN |
分类号 |
A61K31/505;A61K31/519;A61P35/00;C07D471/04;(IPC1-7):C07D471/04 |
主分类号 |
A61K31/505 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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