发明名称 |
ANTISENSE POLYNUCLEOTIDE INHIBITION OF HUMAN GROWTH FACTOR-SENSITIVE CANCER CELLS |
摘要 |
Antisense polynucleotides to human transforming growth factor alpha (TGF- alpha ) and the receptor for human epidermal growth factor (rEGF) are disclosed. Those polynucleotides are about 30 to about 50 bases in length and each hybridizes to about 10 to about 25 bases flanking the start codon for the gene encoding those proteins. Use of those antisense polynucleotides alone, together and mixed with an antibody combining site-containing molecule that binds to rEGF in treating human growth factor-sensitive cancerous tumors such as prostate tumors is also disclosed. |
申请公布号 |
WO9416738(A1) |
申请公布日期 |
1994.08.04 |
申请号 |
WO1994US00964 |
申请日期 |
1994.01.26 |
申请人 |
HEKTOEN INSTITUTE FOR MEDICAL RESEARCH |
发明人 |
RUBENSTEIN, MARVIN |
分类号 |
A61K38/00;C07K16/28;C12N15/113;(IPC1-7):A61K48/00;C12N5/10;C12Q1/68 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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