| 摘要 |
<p>PURPOSE:To obtain a new benzylidene derivative capable of extremely strongly suppressing production of PGE2 and simultaneously suppressing production of cytokinins such as LTbeta4 and IL-1 and expecting antiinflammatory action. CONSTITUTION:A compound of the formula {A is CH2 or CH2CH2; B is direct bond, CH2, CHOH, CO or O, or A and B together form CH=CH; D is N or CH; R<1> and R<2> are H, lower alkyl or lower alkoxy; R<3> is H, lower alkyl, cycloalkyl, lower alkoxy, arylalkyloxy, heteroarylalkyloxy, lower alkylcarbonyl, arylcarbonyl, (substituted)carbamoyl or (CH2)n-R<4> [R<4> is H, OH, amino, aryl, etc.; (n) is 0-3]}, e.g. (E)-2-ethyl-5-(3,5-di-butyl-4-hydroxy)benzylidene-1,2- isothiazolidine-1,1-dioxide.</p> |
