发明名称 |
Enzymatic preparation of optically active propanolol and beta -adrenergic blockers using esterase |
摘要 |
A computer modeling approach is taken to delineate the structural requirements of substrate molecules for biocatalytic turnover and enantioselective discrimination. This leads to an efficient enzymatic preparation of optically active propranolol. The acyl-sustituents on the alcohol and the secondary amine of propranolol play crucial roles in controlling the catalysis and enantiospecificity, respectively, of the enzymatic hydrolysis.
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申请公布号 |
US5334534(A) |
申请公布日期 |
1994.08.02 |
申请号 |
US19920868987 |
申请日期 |
1992.04.15 |
申请人 |
THE BOARD OF GOVERNORS FOR HIGHER EDUCATION, STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS |
发明人 |
CHEN, CHING-SHIH |
分类号 |
C12P13/02;C12P41/00;(IPC1-7):C12P41/00 |
主分类号 |
C12P13/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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