| 摘要 |
PURPOSE:To obtain a novel compound having specific affinity to sigma receptor and useful for the therapy of schizophrenia, etc. CONSTITUTION:The compound of formula I {the nitrogen-containing ring B is 3,3,5,5-tetramethylhexahydro-1H-azepin-1-yl,3,3,5trimethylhexahydro-1H -azepin-1- yl, 4,4-dimethylhexahydro-1H-azepin-1-yl,1,3,3-trimethyl-6-azabicyclo[3,2, 1]octan-6- yl,9-azabicyclo[3,3,2]decan-9-yl,3-azabicyclo[3,2,2]nonan-3-yl; R is H, halogen, OH, nitro, amino; A is 2-3C (un)saturated alkylene}. For example, 1-phenetyl-4,4- dimethylhexahydro-1H-azepine. The compound of formula I is obtained by reacting a compound of formula II with a compound of formula III (X is halogen, etc.; R1 is R) in the presence of a base such as triethylamine in an inert organic solvent. |
