| 摘要 |
A cholinesterase inhibiting agent which contains an alkylene diamine of the formula <CHEM> wherein R<1> and R<2> each independently is a hydrogen atom or a hydrocarbon residue which may optionally be substituted, or R<1> and R<2> combinedly form, together with the adjacent nitrogen atom, a condensed heterocyclic group, R<3> is a hydrogen atom or a hydrocarbon residue or an acyl group which may optionally be substituted and R<4> is a hydrogen atom, or R<3> and R<4> combinedly form a group of the formula -(CH2)m- @-, -@-(CH2)m- or -(CH2)m+1- (m being 0, 1 or 2), A is -(CH2) l - ( l being 0, 1 or 2) or -CH=CH-, X is a substituent or substituents and n is an integer of 4 to 7, or a salt thereof, which are useful as cerebral function improving agents for the prevention or treatment of senile dementia, Alzheimer's disease, Huntington's chorea, hyperkinesia, mania and so forth. |
