发明名称 |
NOVEL NUCLEOSIDE ANALOGS |
摘要 |
Novel oligonucleotide analogs are provided having improved cellular uptake, improved resistance to nucleases, and good hybridization to target RNA. Such analogs are provided having substantially non-chiral, non-ionic linking functionalities between the sugars and sugar analogs thereof. In accordance with preferred embodiments, the 4' position of a sugar or sugar analog at one nucleoside is linked to the 3' position of a second sugar or sugar analog of a second nucleoside by a linking function that comprises a two- or three- carbon backbone chain. In accordance with preferred embodiments, the linking functions comprise the formula)-R1-O where R1 comprises a two or three carbon backbone. Such linking functions also, preferably comprise ether functionalities to effect such linkage. Processes for the automated synthesis of oligonucleotide analogs are also provided. |
申请公布号 |
EP0544792(A4) |
申请公布日期 |
1994.07.27 |
申请号 |
EP19910915853 |
申请日期 |
1991.08.12 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
COOK, PHILIP, DAN;SANGHVI, YOGESH, SHANTILAL |
分类号 |
C07F9/6568;C07D405/04;C07D405/14;C07F7/18;C07H19/04;C07H19/06;C07H19/10;C07H19/16;C07H21/00;C12N15/09 |
主分类号 |
C07F9/6568 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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