发明名称 |
Processes for the preparation of amylase inhibitor |
摘要 |
A process for the preparation of an amylase inhibitor is disclosed which comprises the steps of: (a) extracting wheat, wheat flour or wheat gluten with water, a dilute acid, a dilute alkali or an aqueous alcohol to produce a solution containing the amylase inhibitor; (b) adding a polysaccharide to said solution to form an insoluble complex of the amylase inhibitor with the polysaccharide and separating the insoluble complex from the solution; (c) dissolving or dispersing said complex in a solution, then separating the polysaccharide from the solution to collect a solution containing the amylase inhibitor; and (d) treating the collected solution with a cation exchanger to recover the amylase inhibitor from fractions that have not been adsorbed on the cation exchanger. The amylase inhibitors produced by the above process possess a high amylase inhibitory activity but substantially no trypsin inhibitory activity, and are useful in the prophylaxis and treatment of diseases such as hyperglycemia, diabetes, hyperlipemia, arteriosclerosis and obesity.
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申请公布号 |
US5332803(A) |
申请公布日期 |
1994.07.26 |
申请号 |
US19930049180 |
申请日期 |
1993.04.19 |
申请人 |
NISSHIN FLOUR MILLING CO., LTD.;NAGATA SANGYO CO. LTD. |
发明人 |
MIYAZAKI, TOSHIYUKI;MURAYAMA, RYUJI;MORIMOTO, TOSHIHISA |
分类号 |
A61K38/55;A23L1/03;A61K38/00;A61P3/08;A61P3/10;C07K1/00;C07K1/14;C07K1/18;C07K1/32;C07K14/415;C12N9/99;(IPC1-7):C07K3/02;C07K3/24;C07K3/28;C07K15/10 |
主分类号 |
A61K38/55 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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