| 摘要 |
PURPOSE:To obtain the new disaccharide derivative for immunopotentiators, antitumor agents, antiviral agents, etc., consisting of a disaccharide derivative to which lipid is bound and having strong mitogen activity, adjuvant activity, antitumor activity, antiviral activity, etc. CONSTITUTION:Porphyromanas(Bacteroides) gingivalis (ATCC 33277) which is considered as one causative bacterium of periodontal disease is innoculated into a culture medium and anaerobically cultured at 37 deg.C for 26hr and the cultured mixture is centrifuged to recover the bacterium cell and the cell is subjected to lyophilization to afford a dried bacterial cell and this dried bacterium cell is extracted by heated phenol-water extraction method and the extracted liquid is concentrated and purified with silica gel column chromatography, etc., to provide the new disaccharide derivative for immunopotentiators, antitumor agents, antiviral agents, agents for treating and preventing sepsis, chronic rheumatism, etc., being positive to sulfuric acid, possitive to Dittmer- Lester reaction, negative to ninhydrin reaction and negative to TTC reaction and having a structure expressed by the formula. |
