Processes for producing 5-fluorobenzoic acids and their intermediates

摘要

A process for producing a 5-fluorobenzoic acid of the formula (V), which comprises trichloromethylating a fluorobenzene of the formula (I) to obtain a 5-fluorobenzotrichloride of the formula (II), then reacting it with aqueous ammonia to obtain a 5-fluorobenzonitrile of the formula (III), reacting it with a fluorinating agent to obtain a 5-fluorobenzonitrile of the formula (IV) and hydrolyzing it:h of X1, X3, Y1 and Y3 is a halogen atom, and each of X2 and Y2 is hydrogen or a halogen atom.