发明名称 |
Solid-phase substrate containing modified heparin |
摘要 |
A solid phase substrate which yields soluble labeled products upon hydrolysis by a glycosaminoglycan endoglycosidase and methods of producing said substrate are comprised in the present invention. The solid phase substrate comprises glycosaminoglycan bearing labeled substances bound to amino groups. The labeled glycosaminoglycan substrate is reductively aminated at its reducing terminal end to produce an amine-terminus. The substrate is further coupled to an amino-reactive solid matrix through its amine-terminus.
|
申请公布号 |
US5332812(A) |
申请公布日期 |
1994.07.26 |
申请号 |
US19910776691 |
申请日期 |
1991.10.15 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
NICOLSON, GARTH L.;NAKAJIMA, MOTOWO;IRIMURA, TATSURO |
分类号 |
A61K51/12;C08B37/00;C12N9/24;C12Q1/34;G01N33/573;G01N33/574;(IPC1-7):C07H1/00;C08B37/10 |
主分类号 |
A61K51/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|