发明名称 |
NAPHTHALENEPROPIONIC ACID DERIVATIVES AS ANTI-INFLAMMATORY/ANTIALLERGIC AGENTS |
摘要 |
The invention concerns .alpha.-methyl-6-(2-quinolinyl-methoxy)-2-naphthalene acetic acid, amine salts wherein the amine is an hydroxyalkylamine of formula NR1R2R3 wherein R1 is hydrogen, phenyl, alkyl of 1-6 carbon atoms or hydroxyalkyl of 1-6 carbon atoms, R2 is hydrogen, alkyl of 1-6 carbon atoms or hydroxyalkyl of 1-6 carbon atoms and R3 is hydroxyalkyl of 1-12 carbon atoms. The preferred salts are the tromethamine salts. The amine salts have enhanced activity as compared to the parent acids.
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申请公布号 |
CA1331001(C) |
申请公布日期 |
1994.07.26 |
申请号 |
CA19890613074 |
申请日期 |
1989.09.26 |
申请人 |
AMERICAN HOME PRODUCTS CORPORATION |
发明人 |
KREFT, ANTHONY F., III;MUSSER, JOHN H.;BICKSLER, JAMES J.;GIBERSON, JOHN W.;KUBRAK, DENNIS M. |
分类号 |
A61K31/47;A61P29/00;A61P37/08;A61P43/00;C07C59/68;C07D213/30;C07D215/14;C07D235/12;C07D277/24;C07D277/64;(IPC1-7):C07D215/14 |
主分类号 |
A61K31/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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