发明名称 NAPHTHALENEPROPIONIC ACID DERIVATIVES AS ANTI-INFLAMMATORY/ANTIALLERGIC AGENTS
摘要 The invention concerns .alpha.-methyl-6-(2-quinolinyl-methoxy)-2-naphthalene acetic acid, amine salts wherein the amine is an hydroxyalkylamine of formula NR1R2R3 wherein R1 is hydrogen, phenyl, alkyl of 1-6 carbon atoms or hydroxyalkyl of 1-6 carbon atoms, R2 is hydrogen, alkyl of 1-6 carbon atoms or hydroxyalkyl of 1-6 carbon atoms and R3 is hydroxyalkyl of 1-12 carbon atoms. The preferred salts are the tromethamine salts. The amine salts have enhanced activity as compared to the parent acids.
申请公布号 CA1331001(C) 申请公布日期 1994.07.26
申请号 CA19890613074 申请日期 1989.09.26
申请人 AMERICAN HOME PRODUCTS CORPORATION 发明人 KREFT, ANTHONY F., III;MUSSER, JOHN H.;BICKSLER, JAMES J.;GIBERSON, JOHN W.;KUBRAK, DENNIS M.
分类号 A61K31/47;A61P29/00;A61P37/08;A61P43/00;C07C59/68;C07D213/30;C07D215/14;C07D235/12;C07D277/24;C07D277/64;(IPC1-7):C07D215/14 主分类号 A61K31/47
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