| 摘要 |
<p>Acetal- and ketal-substituted compounds and pharmaceutical compositions thereof have the following formula: CORE MOIETY-(R)j, including resolved enantiomers and/or diastereomers, hydrates, salts, solvates and mixtures thereof. j is an integer from one to three, the core moiety is non-cyclic or cyclic and R may be selected from among hydrogen, halogen, hydroxyl, amino, substituted or unsubstituted alkyl C(1-6), alkenyl C(2-6), cyclic or heterocyclic groups, and groups having a structure prescribed by formula (I). At least one R has the formula (I): -(CH2)n-C-(R1)3, wherein n is an integer from three to twenty; R1 is selected from among hydrogen; halogen; hydroxide; substituted or unsubstituted C(1-6) alkyl, C(1-6) ether, C(2-6) alkenyl, cyclic or heterocyclic group; -OR2, R2 being hydrogen or a substituted or unsubstituted C(1-6) alkyl, C(2-6) alkenyl, cyclic or heterocyclic group; -(CH2)p-C(R3)3 (wherein p is zero or an integer from one to ten, R3 is hydrogen, halogen, hydroxide, substituted or unsubstituted C(1-6) alkyl, C(1-6) ether, C(2-6) alkenyl, cyclic or heterocyclic group, or -OR2, R2 being defined above). The inventive compounds are useful in a large variety of therapeutic indications for treating or preventing disease mediated by intracellular signaling through specific intracellular signaling pathways.</p> |
