| 摘要 |
<p>An ophthalmic solution generally includes an ophthalmologically acceptable drug formulation incompatible with benzalkonium chloride and lauralkonium chloride present in an anti-microbially effective amount. The incompatibility of the ophthalmologically acceptable drug manifests itself by forming insoluble ion pairs with the benzalkonium chloride. It has been found that lauralkonium chloride which is the C12 homolog of benzalkonium chloride is effective as a preservative without apparent interaction with the acidic ophthalmologically acceptable drug and formulations maintain their antimicrobial efficiency over periods of up to one year or more.</p> |
