MELANOGENIC INHIBITOR, AND METHODS OF PRODUCING AND USING THE SAME

摘要

PCT No. PCT/US93/11139 Sec. 371 Date May 24, 1995 Sec. 102(e) Date May 24, 1995 PCT Filed Nov. 16, 1993 PCT Pub. No. WO94/12534 PCT Pub. Date Jun. 9, 1994A purified, naturally derived melanogenic inhibitor protein capable of inhibiting melanogenesis in pigmentary cells has an amino acid sequence SEQ ID NO: 4. A method of producing melanogenic inhibitor protein comprises grafting mammalian skin onto a live host, permitting the mammalian skin to remain on the host for a predetermined period of time, removing the mammalian skin, and extracting the protein from the skin. Methods of controlling melanogenesis in pigmentary cells or selectively destroying melanoma cells comprise the steps of mixing an effective amount of melanogenic inhibitor protein, or an active segment, derivative, or analog thereof, with a suitable carrier, and applying this mixture to the pigmentary or melanoma cells.