| 摘要 |
<p>Compounds of formula (I) and salts and solvates (eg hydrates) thereof, in which R1 represents a hydrogen atom, a halogen atom, C¿1-6?alkyl or C1-6alkoxy; R?2a and R2b¿ each represents H, a halogen atom, C¿1-6?alkoxy, hydroxy or C1-6alkyl; R?3¿ represents the group (a); R?4 and R5¿ each represents H, a halogen atom, hydroxy, C¿1-6?alkoxy or C1-6alkyl; Het represents a group selected from (b), (c), (d), (e), (f), (g), (h) or (i) ; R?6¿ represents a hydrogen atom, -NR9R10 or C¿1-6?alkyl optionally substituted by one or two substituents selected from C1-6alkoxy, hydroxy and -OCOR?11; R6a and R6b¿, each represents H hydroxy or C¿1-6?alkyl optionally substituted by one or two of C1-6alkoxy or hydroxy; R?7, R8 and R9¿ are each H or C¿1-6?alkyl; R?10¿ represents a hydrogen atom C¿1-6?alkyl, COR?11¿, benzoyl or -SO¿2?R?11; R11¿ represents C¿1-6?alkyl or phenyl; V and W each represent oxygen or a sulphur atom; X represents an oxygen atom or the group NR?8¿ or S(O)¿K?; where K is zero, 1 or 2; Y represents an oxygen atom or the group NR?8¿ or SO¿2?; Z represents a sulphur atom or the group NR?8¿; and ----- represents a double bond in either of the positions indicated; are useful in the treatment of depression and other CNS disorders.</p> |
