PROCESS FOR PRODUCING M-CSF 223

摘要

DNA molecules which encode a 255 amino acid polypeptide, comprising the 32 amino acid M-CSF leader sequence and the 223 amino acid mature M-CSF polypeptide, and lack the coding sequence for the carboxy-terminal propeptide sequence present in wild-type M-CSF DNA, result in highly efficient production of M-CSF, which displays similar post-translational modifications as wild-type M-CSF and is unaffected in biological properties.