发明名称 |
Human CNS receptors of the NMDA-R1 family. |
摘要 |
Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. DNA coding for EAA receptors of one family of human NMDA-binding type receptors has now been isolated and receptor proteins characterized. Herein described are recombinant cell lines which produce the EAA receptor as a heterologous membrane-bound product. Also described are related aspects of the invention, which are of commercial significance. Included is use of the cell lines as a tool for discovery of compounds which modulate EAA receptor stimulation. |
申请公布号 |
EP0606734(A1) |
申请公布日期 |
1994.07.20 |
申请号 |
EP19930309950 |
申请日期 |
1993.12.10 |
申请人 |
FOLDES, ROBERT L. |
发明人 |
FOLDES, ROBERT L.;KAMBOJ, RAJENDER |
分类号 |
C07K14/00;C07K14/705;C07K14/715;C07K16/00;C12N5/10;C12N15/09;C12N15/12;C12P21/02;C12P21/08;C12R1/91;G01N33/53;G01N33/566;G01N33/567;G01N33/68 |
主分类号 |
C07K14/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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