Method of protection against (streptococcus pneumoniae) with transformed mycobacteria

摘要

A method of protecting an animal against Streptococcus pneumoniae by administering to the animal mycobacteria which are transformed with DNA which includes at least one DNA sequence which encodes a protein or polypeptide which elicits antibodies against Streptococcus pneumoniae. The at least one DNA sequence may encode a surface protein of Streptococcus pneumoniae, and in particular PspA protein or a fragment or derivative thereof. Such mycobacteria may be administered in combination with a pharmaceutical carrier as a vaccine against Streptococcus pneumoniae.