发明名称 |
Phosphonic acid derivatives and use thereof |
摘要 |
A phosphonic acid derivative compound represented by formula [I ] or a pharmaceutically acceptable salt thereof: <IMAGE> [I] wherein R1, R2 and R3 each represent hydrocarbon groups which may be substituted, except cases in which (1) R2 is unsubstituted methyl, ( 2 ) R3 is an unsubstituted hydrocarbon group having 1 to 3 carbon atoms, and (3) R1 is benzyloxycarbonylaminomethyl, R2 is isobutyl and R3 is isobutyl or phenylmethyl, which has endothelin-converting enzyme inhibiting activity and is useful as pharmaceutical drugs such as therapeutic agents for hypertension, cardiac or cerebral circulatory diseases and renal diseases.
|
申请公布号 |
US5330978(A) |
申请公布日期 |
1994.07.19 |
申请号 |
US19920892768 |
申请日期 |
1992.06.03 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
WAKIMASU, MITSUHIRO;MORI, MASAAKI;KAWADA, AKIRA |
分类号 |
A61K38/00;A61K38/55;A61P9/00;A61P9/12;A61P13/02;A61P15/00;C07K1/06;C07K1/113;C07K5/06;(IPC1-7):C07F9/22;A61K33/42 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|