Growth hormone fusion proteins, methods of production, and methods of treatment

摘要

PCT No. PCT/AU90/00210 Sec. 371 Date Jan. 22, 1991 Sec. 102(e) Date Jan. 22, 1991 PCT Filed May 22, 1990 PCT Pub. No. WO90/15142 PCT Pub. Date Dec. 13, 1990.A plasmid encoding a fusion protein comprising a first polypeptide having growth hormone activity and a second polypeptide which may be one of insulin growth factor (IGF)-I or IGF-II and their analogues, chicken histone H2A.I or human transcription factor SPI-lac Z with an optional cleavage sequence between the first and second polypeptides. The fusion protein may be used: 1) to treat growth hormone deficiencies; 2) to suppress loss of body protein following trauma such as burns or infection; 3) for farm animals to increase growth rates and efficiency of food conversion; 4) and to support growth of cells in culture.