发明名称 |
Effect of N,N,N-trimethylsphingosine on protein kinase-C activity; melanoma cell growth in vitro; metastatic potential in vivo and human platelet aggregation |
摘要 |
PCT No. PCT/US91/09196 Sec. 371 Date Jun. 30, 1993 Sec. 102(e) Date Jun. 30, 1993 PCT Filed Dec. 23, 1991 PCT Pub. No. WO92/12119 PCT Pub. Date Jul. 23, 1992.The invention relates to a novel compound, compositions and medicaments thereof and a method of inhibiting cell proliferation, platelet aggregation (induced by various factors) and inhibiting malignant phenotypes of tumor cells such as those having a metastatic property, and modulating cell adhesion molecule expression and function using said compound, composition or medicament. N,N,N-trimethylsphingosine shows superior cell proliferation inhibitory and anti-metastatic activity over related compounds.
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申请公布号 |
US5331014(A) |
申请公布日期 |
1994.07.19 |
申请号 |
US19930081383 |
申请日期 |
1993.06.30 |
申请人 |
THE BIOMEMBRANE INSTITUTE |
发明人 |
KIMURA, SATOSHI;IGARASHI, YASUYUKI;HAKOMORI, SEN-ITIROH;AHMAD, MOHAMMAD N.;OKOSHI, HIROFUMI;HANDA, KAZUKO |
分类号 |
A61K31/13;A61K31/133;A61P7/02;A61P29/00;A61P35/00;A61P37/00;A61P43/00;C07C215/40;(IPC1-7):A61K31/14 |
主分类号 |
A61K31/13 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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