发明名称 |
Sustained release pharmaceutical composition |
摘要 |
The present invention relates to a pharmaceutical pellet composition having a core element including at least one highly soluble active ingredient and a core coating which is partially soluble at a highly acidic pH. The pharmaceutical composition provides a slow release of active ingredient at a highly acidic pH and provides a constant, relatively faster rate of release at a more alkaline pH such as that of the intestine. Oral administration of the pharmaceutical pellet composition of the present invention to a patient is effective to deliver to the blood levels of active ingredient within the therapeutic range and to maintain such levels over an extended period of time.
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申请公布号 |
US5330766(A) |
申请公布日期 |
1994.07.19 |
申请号 |
US19930007633 |
申请日期 |
1993.01.21 |
申请人 |
F. H. FAULDING & CO. LIMITED |
发明人 |
MORELLA, ANGELO M.;FISHER, MARK C. |
分类号 |
A61K9/22;A61K9/50;A61K9/58;(IPC1-7):A61K9/16;A61K9/30;B05D7/00 |
主分类号 |
A61K9/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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