| 摘要 |
PURPOSE: To form a fibrin sealant which is safe without the contamination with viruses, etc., by bringing a fibrin monomer-contg. compsn. into contact with the section desired to be stanched, etc., and simultaneously converting the fibrin monomer to a fibrin polymer. CONSTITUTION: The compsn. contg. the fibrin monomer (more adequately fibrin enomoner) is brought into contact with the desired section, such as the section to be stanched or the sutured section of tissues and simultaneously the fibrin monomer is converted to the fibrin polymer preferably before 3 seconds of the contact and within 0.5 minutes after the contact. The conversion of the fibrin monomer to the fibrin polymer is executed by bringing an alkaline buffer soln., such as 0.5 to 0.75 M sodium carbonate/sodium bicarbonate, into contact with the compsn. described above in the case the fibrin monomer is obtd. by solubilizing, for example, the non-cross-linked fibrin obtd. from the blood with the acid buffer soln. The non-cross-linked fibrin is preferably obtd. by acting thrombin-like enzyme on plasma. This enzyme is preferably battroxobin. |
